Interleukin-6 requires JAK to stimulate inner cell mass expansion in bovine embryos
نویسندگان
چکیده
منابع مشابه
Interleukin-6 regulates pancreatic -cell mass expansion
*Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zürich, 8091 Zürich, Switzerland; §Department of Genetic Medicine and Development, University Medical Center, CH-1211 Geneva 4, Switzerland; ¶Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium; Diabetes Research Center, Brussels...
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OBJECTIVE The glucoincretin hormone glucagon-like peptide 1 (GLP-1) enhances glucose-stimulated insulin secretion and stimulates pancreatic β-cell mass expansion. We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the β-cell. FoxO1 activity is subject to a complex regulation by Akt-dependent phosphorylation and Sir...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2019
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-19-0286